High pre-cone HR-HPV load predicts persistent infection

This can be scary, I try no to think his far in advanced, but for those who are here:

High pre-cone HR-HPV load predicts persistent infection
Source: Gynecologic Oncology 2007; Advance online publication
Evaluating whether the pre-conization high-risk human papilloma virus
load is associated with the persistence of infection and the
persistence/recurrence of cervical intraepithelial neoplasia after
conization of the cervix.
MedWire News: Women with cervical intraepithelial neoplasia (CIN) are
more likely to have persistent infection and a high rate of recurrent
histologic abnormalities if they have a high pre-conization high-risk
human papilloma virus (HR-HPV) load of more than 100 RLU/PC, study
findings show.
Sang-Soo Seo (National Cancer Center, Goyang-si, Korea) and
colleagues found that women with such a high pre-conization HR-HPV
load were more than five time as likely as women with loads below 100
RLU/PC to have persistent/recurrent histologic abnormalities.
“The persistence of HR-HPV infection of the persistence/recurrence of
histologic abnormalities after conization raises concerns since
persistent HR-HPV infection is linked to persistent or recurrent CIN,
and persistent/recurrent cervical disease can progress to invasive
carcinoma in the absence of an effective treatment,” the researchers
They carried out a retrospective review of 236 women who underwent
conization due to CIN between March 2001 and March 2006. The samples
for pre-conization HR-HPV testing were obtained at least 3 weeks
before conization. All patients underwent HR-HPV testing and cytology
between 3 and 6 months after conization and subsequent follow-up was
conducted at 3- to 6-month intervals thereafter.
High pre-cone HR-HPV load was the only risk factor for persistent HR-
HPV infection, with persistent infection seen in 19.8 percent of
patients with high loads compared with 10.0 percent of patients with
low loads.
Posted: 8 January 2008


January 21, 2008. Uncategorized.

One Comment

  1. Suzanne Patrick replied:


    I’ve been testing for HPV since I have heard of it (for the past 2 1/2 years) and have been testing positive for high risk the whole time. Luckily I’ve only had minor changes so far but I’m scared to death. I want to have children and am already 32 years old.

    I don’t know what’s going to happen. I wish there was some type of treatment or medication we could take other than surgery. I’ve read a lot of horror stories about people who have been faithful about appointments and have gotten paps on a regular basis but have still gone on to develop invasive cancer.

    The person I was with was on drugs (I didn’t know it at the time) and he had sex with several prostitutes.

    It’s scary. If you have any good advice, please let me know. The doctors pretty much just blow me off and I think a lot of the funding for a therapeutic vaccine is going out the window with the $ now going toward prevention. Even ASHA must be losing funding b/c no one even answers their phones.


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